This study reviews how Mesenchymal Stem Cells Cooperate with Bone Marrow Cells in Therapy of Diabetes. At Dream Body Clinic we use mesenchymal stem cells administered at 300 million MSCs in an IV for the treatment of Type 2 Diabetes. Learn more about dream body clinic’s type 2 diabetes stem cell therapy here.
ABSTRACT : Mesenchymal Stem Cells Cooperate with Bone Marrow Cells in Therapy of Diabetes
Several recent studies have suggested that the adult bone marrow harbors cells that can influence -cell regeneration in diabetic animals. Other reports, however, have contradicted these findings. To address this issue, we used an animal model of type 1 diabetes in which the disease was induced with streptozotocin in mice. Freshly prepared sex-mismatched bone marrow cells (BMCs) and syngeneic orallogeneic mesenchymal stem cells (MSCs) were concomi-tantly administrated into sublethally irradiated diabeticmice. Blood glucose and serum insulin concentrations rap-idly returned to normal levels, accompanied by efficient tissue regeneration after a single injection of a mixture of 106BMCs per 105MSCs. Neither BMC nor MSC transplantation was effective alone. Successful treatment of diabetic animals was not due to the reconstitution of the damagedislet cells from the transplant, since no donor-derived-cells were found in the recovered animals, indicating a graft-initiated endogenous repair process. Moreover, MSC injection caused the disappearance of -cell-specific T lymphocytes from diabetic pancreas. Therefore, we suggest that two aspects of this successful treatment regimen operate in parallel and synergistically in our model. First, BMC sand MSCs induce the regeneration of recipient-derived pancreatic insulin-secreting cells. Second, MSCs inhibit T-cell-mediated immune responses against newly formed-cells, which, in turn, are able to survive in this altered immunological milieu. Thus, the application of this therapy in human patients suffering from diabetes and/or other tissue destructive autoimmune diseases may be feasible. STEM CELLS 2008;26:244–253
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